There are no scientific studies in MS that specifically address wayfinding. One older paper mentions it as one of several everyday memory problems.

Haupts M, Calabrese P, Babinsky R, Markowitsch HJ, Gehlen W. Everyday memory impairment, neuroradiological findings and physical disability in multiple sclerosis. Eur J Neurol. 1994 Nov;1(2):159-63.

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